SCHEDULE 13G/A

Rhythm Pharmaceuticals Inc

Common Stock, par value $0.001 per share · CUSIP: 76243J105

Event date: 2025-03-31

Reporting persons may disclose overlapping interests. Their amounts are shown individually and are not added into a filing total.

Filing-level shares

Unavailable

Percent of class

Unavailable

• Baker Bros. Advisors LP

  Shares: 5,604,483.00 · Class: 8.9%

• Baker Bros. Advisors (GP) LLC

  Shares: 5,604,483.00 · Class: 8.9%

• Julian C. Baker

  Shares: 5,604,483.00 · Class: 8.9%

• Felix J. Baker

  Shares: 5,604,483.00 · Class: 8.9%

Amounts are as disclosed in this filing. Schedule type alone does not establish investment intent.