SCHEDULE 13G/A

Trevi Therapeutics Inc

Common Stock, $0.001 par value per share · CUSIP: 89532M101

Event date: 2025-09-30

Reporting persons may disclose overlapping interests. Their amounts are shown individually and are not added into a filing total.

Filing-level shares

Unavailable

Percent of class

Unavailable

• Frazier Life Sciences Public Fund, L.P.

  Shares: 8,508,021.00 · Class: 7.0%

• FHMLSP, L.P.

  Shares: 8,508,021.00 · Class: 7.0%

• FHMLSP, L.L.C.

  Shares: 8,508,021.00 · Class: 7.0%

• Frazier Life Sciences X, L.P.

  Shares: 397,309.00 · Class: 0.3%

• FHMLS X, L.P.

  Shares: 397,309.00 · Class: 0.3%

• FHMLS X, L.L.C.

  Shares: 397,309.00 · Class: 0.3%

• Frazier Life Sciences XI, L.P.

  Shares: 1,354,079.00 · Class: 1.1%

• FHMLS XI, L.P.

  Shares: 1,354,079.00 · Class: 1.1%

• FHMLS XI, L.L.C.

  Shares: 1,354,079.00 · Class: 1.1%

• James N. Topper

  Shares: 397,309.00 · Class: 0.3%

• Patrick J. Heron

  Shares: 397,309.00 · Class: 0.3%

• Albert Cha

  Shares: 0.00 · Class: 0.0%

• James Brush

  Shares: 0.00 · Class: 0.0%

• Daniel Estes

  Shares: 0.00 · Class: 0.0%

Amounts are as disclosed in this filing. Schedule type alone does not establish investment intent.