SCHEDULE 13G

OnKure Therapeutics, Inc.

Class A Common Stock, par value $0.0001 per share · CUSIP: 68277Q105

Event date: 2025-11-24

Reporting persons may disclose overlapping interests. Their amounts are shown individually and are not added into a filing total.

Filing-level shares

Unavailable

Percent of class

Unavailable

• Prosight Management, LP

  Shares: 745,649.00 · Class: 5.8%

• Prosight Fund, LP

  Shares: 35,514.00 · Class: 0.3%

• Prosight Plus Fund, LP

  Shares: 163,487.00 · Class: 1.3%

• Prosight Partners, LLC

  Shares: 745,649.00 · Class: 5.8%

• W. Lawrence Hawkins

  Shares: 745,649.00 · Class: 5.8%

Amounts are as disclosed in this filing. Schedule type alone does not establish investment intent.