SCHEDULE 13G/A

SOL-GEL TECHNOLOGIES LTD

Ordinary Shares, par value NIS 1.00 per share. · CUSIP: M8694L137

Event date: 2025-11-13

Reporting persons may disclose overlapping interests. Their amounts are shown individually and are not added into a filing total.

Filing-level shares

Unavailable

Percent of class

Unavailable

• Opaleye Management Inc.

  Shares: 367,367.00 · Class: 13.19%

• Opaleye, L.P.

  Shares: 357,367.00 · Class: 12.83%

• James Silverman

  Shares: 367,367.00 · Class: 13.19%

Amounts are as disclosed in this filing. Schedule type alone does not establish investment intent.