SCHEDULE 13G/A

CRESCENT BIOPHARMA INC.

Ordinary Shares, $0.001 par value per share · CUSIP: G2545C104

Event date: 2025-06-30

Reporting persons may disclose overlapping interests. Their amounts are shown individually and are not added into a filing total.

Filing-level shares

Unavailable

Percent of class

Unavailable

• BIOTECHNOLOGY VALUE FUND L P

  Shares: 707,116.00 · Class: 5.1%

• BVF I GP LLC

  Shares: 707,116.00 · Class: 5.1%

• BIOTECHNOLOGY VALUE FUND II LP

  Shares: 593,740.00 · Class: 4.3%

• BVF II GP LLC

  Shares: 593,740.00 · Class: 4.3%

• Biotechnology Value Trading Fund OS LP

  Shares: 62,383.00 · Class: 0.4%

• BVF Partners OS Ltd.

  Shares: 62,383.00 · Class: 0.4%

• BVF GP HOLDINGS LLC

  Shares: 1,300,856.00 · Class: 9.4%

• BVF PARTNERS L P/IL

  Shares: 1,387,863.00 · Class: 9.99%

• BVF INC/IL

  Shares: 1,387,863.00 · Class: 9.99%

• LAMPERT MARK N

  Shares: 1,387,863.00 · Class: 9.99%

Amounts are as disclosed in this filing. Schedule type alone does not establish investment intent.