SCHEDULE 13G/A

Adagene Inc.

Ordinary Shares · CUSIP: 005329107

Event date: 2025-12-31

Reporting persons may disclose overlapping interests. Their amounts are shown individually and are not added into a filing total.

Filing-level shares

Unavailable

Percent of class

Unavailable

• Smith Vincent C

  Shares: 5,095,351.25 · Class: 8.7%

• The Vincent C. Smith, Jr. 2025 Annuity Trust

  Shares: 3,608,018.75 · Class: 6.1%

• VCS Master Holdings GP

  Shares: 185,701.25 · Class: 1.0%

Amounts are as disclosed in this filing. Schedule type alone does not establish investment intent.