SCHEDULE 13G/A

SAB Biotherapeutics, Inc.

Common Stock, $0.0001 par value per share · CUSIP: 78397T202

Event date: 2025-09-30

Reporting persons may disclose overlapping interests. Their amounts are shown individually and are not added into a filing total.

Filing-level shares

Unavailable

Percent of class

Unavailable

• BIOTECHNOLOGY VALUE FUND L P

  Shares: 3,041,111.00 · Class: 6.1%

• BVF I GP LLC

  Shares: 3,041,111.00 · Class: 6.1%

• BIOTECHNOLOGY VALUE FUND II LP

  Shares: 2,075,714.00 · Class: 4.2%

• BVF II GP LLC

  Shares: 2,075,714.00 · Class: 4.2%

• Biotechnology Value Trading Fund OS LP

  Shares: 44,444.00 · Class: 0.09%

• BVF Partners OS Ltd.

  Shares: 44,444.00 · Class: 0.09%

• BVF GP HOLDINGS LLC

  Shares: 5,116,825.00 · Class: 9.90%

• BVF PARTNERS L P/IL

  Shares: 5,167,618.00 · Class: 9.99%

• BVF INC/IL

  Shares: 5,167,618.00 · Class: 9.99%

• LAMPERT MARK N

  Shares: 5,167,618.00 · Class: 9.99%

Amounts are as disclosed in this filing. Schedule type alone does not establish investment intent.