SCHEDULE 13D/A

SPRUCE BIOSCIENCES INC

Common Stock, par value $0.001 per share · CUSIP: 85209E109

Event date: 2025-01-07

Reporting persons may disclose overlapping interests. Their amounts are shown individually and are not added into a filing total.

Filing-level shares

Unavailable

Percent of class

Unavailable

• RiverVest Venture Fund III, L.P.Reported CIK 0001601559

  Shares: 720,656.00 · Class: 0.2%

• RiverVest Venture Fund III (Ohio), L.P.Reported CIK 0001636686

  Shares: 38,251.00 · Class: 0.1%

• RiverVest Venture Partners III (Ohio), LLCReported CIK 0001752269

  Shares: 38,251.00 · Class: 0.1%

• RiverVest Venture Partners III, L.P.Reported CIK 0001752268

  Shares: 758,907.00 · Class: 0.2%

• RiverVest Venture Partners III, LLCReported CIK 0001752405

  Shares: 758,907.00 · Class: 0.2%

• RiverVest Venture Fund IV, L.P.Reported CIK 0001725443

  Shares: 1,000,614.00 · Class: 2.4%

• RiverVest Venture Partners IV, L.P.

  Shares: 1,000,614.00 · Class: 2.4%

• RiverVest Venture Partners IV, LLC

  Shares: 1,000,614.00 · Class: 2.4%

• John P. McKearn, Ph.D.Reported CIK 0001240120

  Shares: 1,759,521.00 · Class: 4.2%

• Jay SchmelterReported CIK 0001435248

  Shares: 1,759,521.00 · Class: 4.2%

• Thomas C. MelzerReported CIK 0001611651

  Shares: 758,907.00 · Class: 0.2%

• Niall O'Donnell, Ph.D.Reported CIK 0001780235

  Shares: 1,000,614.00 · Class: 2.4%

Amounts are as disclosed in this filing. Schedule type alone does not establish investment intent.