SCHEDULE 13G/A

Protagonist Therapeutics Inc

Common Stock, $0.00001 par value per share · CUSIP: 74366E102

Event date: 2025-09-30

Reporting persons may disclose overlapping interests. Their amounts are shown individually and are not added into a filing total.

Filing-level shares

Unavailable

Percent of class

Unavailable

• BIOTECHNOLOGY VALUE FUND L P

  Shares: 1,323,333.00 · Class: 2.1%

• BVF I GP LLC

  Shares: 1,323,333.00 · Class: 2.1%

• BIOTECHNOLOGY VALUE FUND II LP

  Shares: 1,045,774.00 · Class: 1.7%

• BVF II GP LLC

  Shares: 1,045,774.00 · Class: 1.7%

• Biotechnology Value Trading Fund OS LP

  Shares: 140,917.00 · Class: 0.2%

• BVF Partners OS Ltd.

  Shares: 140,917.00 · Class: 0.2%

• BVF GP HOLDINGS LLC

  Shares: 2,369,107.00 · Class: 3.8%

• BVF PARTNERS L P/IL

  Shares: 2,560,916.00 · Class: 4.1%

• BVF INC/IL

  Shares: 2,560,916.00 · Class: 4.1%

• LAMPERT MARK N

  Shares: 2,560,916.00 · Class: 4.1%

Amounts are as disclosed in this filing. Schedule type alone does not establish investment intent.