SCHEDULE 13D/A

Taysha Gene Therapies Inc

Common Stock, $0.00001 par value per share · CUSIP: 877619106

Event date: 2025-05-30

Reporting persons may disclose overlapping interests. Their amounts are shown individually and are not added into a filing total.

Filing-level shares

Unavailable

Percent of class

Unavailable

• Paul B ManningReported CIK 0001494695

  Shares: 25,601,111.00 · Class: 9.8%

• The Paul B. Manning Revocable Trust dated May 10, 2000Reported CIK 0000000009

  Shares: 14,723,948.12 · Class: 5.6%

• The PBM 2023 Grantor Retained Annuity TrustReported CIK 0001234567

  Shares: 4,013,458.88 · Class: 1.5%

• The PBM 2025 Grantor Retained Annuity TrustReported CIK 0001234569

  Shares: 4,000,000.00 · Class: 1.5%

• BKB Growth Investments, LLCReported CIK 0001234568

  Shares: 2,841,704.00 · Class: 1.1%

• BKB G2 Investments, LLCReported CIK 0001234570

  Shares: 22,000.00 · Class: 0.0%

Amounts are as disclosed in this filing. Schedule type alone does not establish investment intent.