SCHEDULE 13G/A

XILIO THERAPEUTICS INC

Common Stock, par value $0.0001 per share · CUSIP: 98422T100

Event date: 2025-12-31

Reporting persons may disclose overlapping interests. Their amounts are shown individually and are not added into a filing total.

Filing-level shares

Unavailable

Percent of class

Unavailable

• Frazier Life Sciences Public Fund, L.P.

  Shares: 4,676,472.00 · Class: 6.7%

• FHMLSP, L.P.

  Shares: 4,676,472.00 · Class: 6.7%

• FHMLSP, L.L.C.

  Shares: 4,676,472.00 · Class: 6.7%

• Frazier Life Sciences X, L.P.

  Shares: 149,060.00 · Class: 0.2%

• FHMLS X, L.P.

  Shares: 149,060.00 · Class: 0.2%

• FHMLS X, L.L.C.

  Shares: 149,060.00 · Class: 0.2%

• Frazier Life Sciences XI, L.P.

  Shares: 396,902.00 · Class: 0.6%

• FHMLS XI, L.P.

  Shares: 396,902.00 · Class: 0.6%

• FHMLS XI, L.L.C.

  Shares: 396,902.00 · Class: 0.6%

• Frazier Life Sciences XII, L.P.

  Shares: 692,657.00 · Class: 1.0%

• FHMLS XII, L.P.

  Shares: 692,657.00 · Class: 1.0%

• FHMLS XII, L.L.C.

  Shares: 692,657.00 · Class: 1.0%

• James N. Topper

  Shares: 149,060.00 · Class: 0.2%

• Patrick J. Heron

  Shares: 149,060.00 · Class: 0.2%

Amounts are as disclosed in this filing. Schedule type alone does not establish investment intent.