SCHEDULE 13G

Amylyx Pharmaceuticals Inc

Common Stock, $0.0001 par value per share · CUSIP: 03237H101

Event date: 2025-11-10

Reporting persons may disclose overlapping interests. Their amounts are shown individually and are not added into a filing total.

Filing-level shares

Unavailable

Percent of class

Unavailable

• Commodore Capital LP

  Shares: 5,650,000.00 · Class: 5.1%

• Commodore Capital Master LP

  Shares: 5,650,000.00 · Class: 5.1%

• Robert Egen Atkinson

  Shares: 5,650,000.00 · Class: 5.1%

• Michael Kramarz

  Shares: 5,650,000.00 · Class: 5.1%

Amounts are as disclosed in this filing. Schedule type alone does not establish investment intent.