SCHEDULE 13G/A

Praxis Precision Medicines Inc

Common Stock, par value $0.0001 per share · CUSIP: 74006W207

Event date: 2025-12-31

Reporting persons may disclose overlapping interests. Their amounts are shown individually and are not added into a filing total.

Filing-level shares

Unavailable

Percent of class

Unavailable

• Point72 Asset Management, L.P.

  Shares: 1,503,376.00 · Class: 5.9%

• Point72 Capital Advisors, Inc.

  Shares: 1,503,376.00 · Class: 5.9%

• Point72 Biotech Private Investments, LLC

  Shares: 65,933.00 · Class: 0.3%

• Differentiated Ventures Investments, LLC

  Shares: 65,933.00 · Class: 0.3%

• 72 Investment Holdings, LLC

  Shares: 65,933.00 · Class: 0.3%

• Steven A. Cohen

  Shares: 1,569,309.00 · Class: 6.1%

Amounts are as disclosed in this filing. Schedule type alone does not establish investment intent.