SCHEDULE 13G

CRESCENT BIOPHARMA INC.

Ordinary Shares, $0.001 par value per share · CUSIP: 38000Q201

Event date: 2025-06-13

Reporting persons may disclose overlapping interests. Their amounts are shown individually and are not added into a filing total.

Filing-level shares

Unavailable

Percent of class

Unavailable

• Venrock Healthcare Capital Partners III, L.P.

  Shares: 1,391,196.00 · Class: 9.9%

• VHCP Co-Investment Holdings III, LLC

  Shares: 1,391,196.00 · Class: 9.9%

• Venrock Healthcare Capital Partners EG, L.P.

  Shares: 1,391,196.00 · Class: 9.9%

• VHCP Management III, LLC

  Shares: 1,391,196.00 · Class: 9.9%

• VHCP Management EG, LLC

  Shares: 1,391,196.00 · Class: 9.9%

• Nimish Shah

  Shares: 1,391,196.00 · Class: 9.9%

• Bong Y. Koh

  Shares: 1,391,196.00 · Class: 9.9%

Amounts are as disclosed in this filing. Schedule type alone does not establish investment intent.