SCHEDULE 13G/A

Spyre Therapeutics Inc

Common Stock, par value $0.0001 per share · CUSIP: 00773J202

Event date: 2024-12-31

Reporting persons may disclose overlapping interests. Their amounts are shown individually and are not added into a filing total.

Filing-level shares

Unavailable

Percent of class

Unavailable

• Venrock Healthcare Capital Partners III, L.P.

  Shares: 2,685,448.00 · Class: 4.6%

• VHCP Co-Investment Holdings III, LLC

  Shares: 2,685,448.00 · Class: 4.6%

• Venrock Healthcare Capital Partners EG, L.P.

  Shares: 2,685,448.00 · Class: 4.6%

• VHCP Management III, LLC

  Shares: 2,685,448.00 · Class: 4.6%

• VHCP Management EG, LLC

  Shares: 2,685,448.00 · Class: 4.6%

• Nimish Shah

  Shares: 2,685,448.00 · Class: 4.6%

• Bong Y Koh

  Shares: 2,685,448.00 · Class: 4.6%

Amounts are as disclosed in this filing. Schedule type alone does not establish investment intent.