SCHEDULE 13G/A

Karyopharm Therapeutics Inc

Common Stock, par value $0.0001 per share · CUSIP: 48576U205

Event date: 2026-09-30

Reporting persons may disclose overlapping interests. Their amounts are shown individually and are not added into a filing total.

Filing-level shares

Unavailable

Percent of class

Unavailable

• Integrated Core Strategies (US) LLC

  Shares: 42,888.00 · Class: 0.2%

• Millennium Management LLC

  Shares: 42,888.00 · Class: 0.2%

• Millennium Group Management LLC

  Shares: 42,888.00 · Class: 0.2%

• Israel A. Englander

  Shares: 42,888.00 · Class: 0.2%

Amounts are as disclosed in this filing. Schedule type alone does not establish investment intent.