SCHEDULE 13G

Palisade Bio, Inc.

Common Stock, par value $0.01 per share · CUSIP: 696389402

Event date: 2025-10-02

Reporting persons may disclose overlapping interests. Their amounts are shown individually and are not added into a filing total.

Filing-level shares

Unavailable

Percent of class

Unavailable

• RA Capital Management, L.P.

  Shares: 9,935,761.00 · Class: 9.9%

• Peter Kolchinsky

  Shares: 9,935,761.00 · Class: 9.9%

• Rajeev Shah

  Shares: 9,935,761.00 · Class: 9.9%

• RA Capital Healthcare Fund, L.P.

  Shares: 9,935,761.00 · Class: 9.9%

Amounts are as disclosed in this filing. Schedule type alone does not establish investment intent.