SCHEDULE 13G

XILIO THERAPEUTICS INC

Common Stock, par value $0.0001 per share · CUSIP: 98422T100

Event date: 2025-06-05

Reporting persons may disclose overlapping interests. Their amounts are shown individually and are not added into a filing total.

Filing-level shares

Unavailable

Percent of class

Unavailable

• Frazier Life Sciences Public Fund, L.P.

  Shares: 3,508,661.00 · Class: 6.3%

• FHMLSP, L.P.

  Shares: 3,508,661.00 · Class: 6.3%

• FHMLSP, L.L.C.

  Shares: 3,508,661.00 · Class: 6.3%

• Frazier Life Sciences Public Overage Fund, L.P.

  Shares: 1,035,069.00 · Class: 2.0%

• FHMLSP Overage, L.P.

  Shares: 1,035,069.00 · Class: 2.0%

• FHMLSP Overage, L.L.C.

  Shares: 1,035,069.00 · Class: 2.0%

• Frazier Life Sciences X, L.P.

  Shares: 144,829.00 · Class: 0.3%

• FHMLS X, L.P.

  Shares: 144,829.00 · Class: 0.3%

• FHMLS X, L.L.C.

  Shares: 144,829.00 · Class: 0.3%

• Frazier Life Sciences XI, L.P.

  Shares: 385,637.00 · Class: 0.7%

• FHMLS XI, L.P.

  Shares: 385,637.00 · Class: 0.7%

• FHMLS XI, L.L.C.

  Shares: 385,637.00 · Class: 0.7%

• Frazier Life Sciences XII, L.P.

  Shares: 672,997.00 · Class: 1.3%

• FHMLS XII, L.P.

  Shares: 672,997.00 · Class: 1.3%

• FHMLS XII, L.L.C.

  Shares: 672,997.00 · Class: 1.3%

• James N. Topper

  Shares: 5,747,193.00 · Class: 9.9%

• Patrick J. Heron

  Shares: 5,747,193.00 · Class: 9.9%

• Albert Cha

  Shares: 4,543,730.00 · Class: 8.1%

• James Brush

  Shares: 4,543,730.00 · Class: 8.1%

• Daniel Estes

  Shares: 1,058,634.00 · Class: 2.0%

Amounts are as disclosed in this filing. Schedule type alone does not establish investment intent.