SCHEDULE 13G/A

IONIS PHARMACEUTICALS INC

Common Stock · CUSIP: 462222100

Event date: 2025-06-30

Reporting persons may disclose overlapping interests. Their amounts are shown individually and are not added into a filing total.

Filing-level shares

Unavailable

Percent of class

Unavailable

• Wellington Management Group LLP

  Shares: 6,879,873.00 · Class: 4.3%

• Wellington Group Holdings LLP

  Shares: 6,879,873.00 · Class: 4.3%

• Wellington Investment Advisors Holdings LLP

  Shares: 6,879,873.00 · Class: 4.3%

Amounts are as disclosed in this filing. Schedule type alone does not establish investment intent.