SCHEDULE 13G/A

OnKure Therapeutics, Inc.

Class A Common Stock, par value $0.0001 per share (the "Shares") · CUSIP: 68277Q105

Event date: 2025-12-31

Reporting persons may disclose overlapping interests. Their amounts are shown individually and are not added into a filing total.

Filing-level shares

Unavailable

Percent of class

Unavailable

• Citadel Advisors LLC

  Shares: 48,957.00 · Class: 0.4%

• Citadel Advisors Holdings LP

  Shares: 48,957.00 · Class: 0.4%

• Citadel GP LLC

  Shares: 48,957.00 · Class: 0.4%

• Citadel Securities LLC

  Shares: 174,168.00 · Class: 1.4%

• Citadel Securities Group LP

  Shares: 174,168.00 · Class: 1.4%

• Citadel Securities GP LLC

  Shares: 174,168.00 · Class: 1.4%

• Kenneth Griffin

  Shares: 223,125.00 · Class: 1.7%

Amounts are as disclosed in this filing. Schedule type alone does not establish investment intent.