SCHEDULE 13G/A

Codexis Inc

Common Stock, par value $0.0001 per share · CUSIP: 192005106

Event date: 2025-12-31

Reporting persons may disclose overlapping interests. Their amounts are shown individually and are not added into a filing total.

Filing-level shares

Unavailable

Percent of class

Unavailable

• Opaleye Management Inc.

  Shares: 6,789,738.00 · Class: 7.52%

• Opaleye, L.P.

  Shares: 6,669,738.00 · Class: 7.38%

• James Silverman

  Shares: 6,789,738.00 · Class: 7.52%

Amounts are as disclosed in this filing. Schedule type alone does not establish investment intent.