SCHEDULE 13D/A

SKYE BIOSCIENCE INC

Common Stock, par value $0.001 · CUSIP: 83086J200

Event date: 2025-12-12

Reporting persons may disclose overlapping interests. Their amounts are shown individually and are not added into a filing total.

Filing-level shares

Unavailable

Percent of class

Unavailable

• 5AM Partners VII, LLCReported CIK 0001873545

  Shares: 9,872,599.00 · Class: 29.2%

• 5AM Ventures VII, L.P.Reported CIK 0001844435

  Shares: 9,872,599.00 · Class: 29.2%

• 5AM Partners II, LLCReported CIK 0001555952

  Shares: 1,514,557.00 · Class: 4.7%

• 5AM Ventures II, L.P.Reported CIK 0001386509

  Shares: 1,457,064.00 · Class: 4.5%

• 5AM Co-Investors II, L.P.Reported CIK 0001390376

  Shares: 57,493.00 · Class: 0.2%

• Andrew J. SchwabReported CIK 0001598549

  Shares: 11,541,317.00 · Class: 34.0%

• Kush ParmarReported CIK 0001664281

  Shares: 9,872,599.00 · Class: 29.2%

• John D. DiekmanReported CIK 0001240357

  Shares: 1,514,557.00 · Class: 4.7%

• Scott M. RocklageReported CIK 0001219014

  Shares: 1,514,557.00 · Class: 4.7%

Amounts are as disclosed in this filing. Schedule type alone does not establish investment intent.