SCHEDULE 13G

Protagonist Therapeutics Inc

Common Stock, $0.00001 par value per share · CUSIP: 74366E102

Event date: 2025-06-09

Reporting persons may disclose overlapping interests. Their amounts are shown individually and are not added into a filing total.

Filing-level shares

Unavailable

Percent of class

Unavailable

• BIOTECHNOLOGY VALUE FUND L P

  Shares: 1,681,652.00 · Class: 2.7%

• BVF I GP LLC

  Shares: 1,681,652.00 · Class: 2.7%

• BIOTECHNOLOGY VALUE FUND II LP

  Shares: 1,280,665.00 · Class: 2.1%

• BVF II GP LLC

  Shares: 1,280,665.00 · Class: 2.1%

• Biotechnology Value Trading Fund OS LP

  Shares: 181,190.00 · Class: 0.3%

• BVF Partners OS Ltd.

  Shares: 181,190.00 · Class: 0.3%

• BVF GP HOLDINGS LLC

  Shares: 2,962,317.00 · Class: 4.8%

• BVF PARTNERS L P/IL

  Shares: 3,211,041.00 · Class: 5.2%

• BVF INC/IL

  Shares: 3,211,041.00 · Class: 5.2%

• LAMPERT MARK N

  Shares: 3,211,041.00 · Class: 5.2%

Amounts are as disclosed in this filing. Schedule type alone does not establish investment intent.