SCHEDULE 13G

BICYCLE THERAPEUTICS PLC

Ordinary Shares, nominal value GBP 0.01 per share · CUSIP: 088786108

Event date: 2026-02-25

Reporting persons may disclose overlapping interests. Their amounts are shown individually and are not added into a filing total.

Filing-level shares

Unavailable

Percent of class

Unavailable

• Invus Public Equities, L.P.

  Shares: 2,719,707.00 · Class: 5.4%

• Invus Public Equities Advisors, LLC

  Shares: 2,719,707.00 · Class: 5.4%

• Invus Global Management, LLC

  Shares: 2,719,707.00 · Class: 5.4%

• Siren, L.L.C.

  Shares: 2,719,707.00 · Class: 5.4%

• Avicenna Life Sci Master Fund LP

  Shares: 429,342.00 · Class: 0.9%

• Avicenna Life Sci Master GP LLC

  Shares: 429,342.00 · Class: 0.9%

• Ulys, L.L.C.

  Shares: 429,342.00 · Class: 0.9%

• Raymond Debbane

  Shares: 3,149,049.00 · Class: 6.3%

Amounts are as disclosed in this filing. Schedule type alone does not establish investment intent.