SCHEDULE 13D/A

HYPERION DEFI INC

COMMON STOCK, par value $0.0001 per share · CUSIP: 30234E203

Event date: 2025-09-17

Reporting persons may disclose overlapping interests. Their amounts are shown individually and are not added into a filing total.

Filing-level shares

Unavailable

Percent of class

Unavailable

• Avenue Venture Opportunities Fund, L.P.Reported CIK 0001792691

  Shares: 96,049.00 · Class: 1.7%

• Avenue Venture Opportunities Fund II, L.P.Reported CIK 0001886343

  Shares: 144,075.00 · Class: 2.5%

• Avenue Capital Management II, L.P.Reported CIK 0001317338

  Shares: 240,124.00 · Class: 4.2%

• Avenue Venture Opportunities Partners, LLC

  Shares: 96,049.00 · Class: 1.7%

• Avenue Venture Opportunities Partners II, LLC

  Shares: 144,075.00 · Class: 2.5%

• GL Venture Opportunities Partners, LLC

  Shares: 96,049.00 · Class: 1.7%

• GL Venture Opportunities Partners II, LLC

  Shares: 144,075.00 · Class: 2.5%

• Marc LasryReported CIK 0001259927

  Shares: 240,124.00 · Class: 4.2%

Amounts are as disclosed in this filing. Schedule type alone does not establish investment intent.