SCHEDULE 13D/A

Lexicon Pharmaceuticals Inc

Common Stock, par value $0.001 per share · CUSIP: 528872302

Event date: 2026-01-29

Reporting persons may disclose overlapping interests. Their amounts are shown individually and are not added into a filing total.

Filing-level shares

Unavailable

Percent of class

Unavailable

• Invus, L.P.Reported CIK 0001404570

  Shares: 42,765,057.00 · Class: 10.0%

• Invus Advisors, L.L.C.

  Shares: 42,765,057.00 · Class: 10.0%

• Invus Public Equities, L.P.

  Shares: 7,362,368.00 · Class: 1.7%

• Invus Public Equities Advisors, LLC

  Shares: 7,362,368.00 · Class: 1.7%

• Invus Global Management, LLCReported CIK 0002005369

  Shares: 42,765,057.00 · Class: 10.0%

• Siren, L.L.C.

  Shares: 42,765,057.00 · Class: 10.0%

• Avicenna Life Sci Master Fund LP

  Shares: 1,538,462.00 · Class: 0.4%

• Avicenna Life Sci Master GP LLC

  Shares: 1,538,462.00 · Class: 0.4%

• Invus US Partners LLC

  Shares: 5,451,204.00 · Class: 1.3%

• Ulys, L.L.C.Reported CIK 0001218180

  Shares: 6,989,666 · Class: 1.6%

• Mr. Raymond Debbane

  Shares: 51,217,900 · Class: 12.0%

• Artal Participations S.a r.l.

  Shares: 154,734,327.00 · Class: 36.2%

• Artal International S.C.A.

  Shares: 154,734,327.00 · Class: 36.2%

• Artal International Management S.A.

  Shares: 154,734,327.00 · Class: 36.2%

• Artal Group S.A.

  Shares: 154,734,327.00 · Class: 36.2%

• Westend S.A.

  Shares: 154,734,327.00 · Class: 36.2%

• Stichting Administratiekantoor Westend

  Shares: 154,734,327.00 · Class: 36.2%

• Mr. Amaury Wittouck

  Shares: 154,734,327.00 · Class: 36.2%

Amounts are as disclosed in this filing. Schedule type alone does not establish investment intent.