SCHEDULE 13D/A

REPARE THERAPEUTICS INC

Common Shares, no par value · CUSIP: 760273102

Event date: 2025-11-20

Reporting persons may disclose overlapping interests. Their amounts are shown individually and are not added into a filing total.

Filing-level shares

Unavailable

Percent of class

Unavailable

• BIOTECHNOLOGY VALUE FUND L PReported CIK 0000918923

  Shares: 5,309,432.00 · Class: 12.4%

• BVF I GP LLCReported CIK 0001803805

  Shares: 5,309,432.00 · Class: 12.4%

• BIOTECHNOLOGY VALUE FUND II LPReported CIK 0001102444

  Shares: 4,308,573.00 · Class: 10.0%

• BVF II GP LLCReported CIK 0001803806

  Shares: 4,308,573.00 · Class: 10.0%

• Biotechnology Value Trading Fund OS LPReported CIK 0001660683

  Shares: 548,938.00 · Class: 1.3%

• BVF Partners OS Ltd.Reported CIK 0001660684

  Shares: 548,938.00 · Class: 1.3%

• BVF GP HOLDINGS LLCReported CIK 0001803809

  Shares: 9,618,005.00 · Class: 22.4%

• BVF PARTNERS L P/ILReported CIK 0001055947

  Shares: 10,333,600.00 · Class: 24.0%

• BVF INC/ILReported CIK 0001056807

  Shares: 10,333,600.00 · Class: 24.0%

• LAMPERT MARK NReported CIK 0001233840

  Shares: 10,333,600.00 · Class: 24.0%

Amounts are as disclosed in this filing. Schedule type alone does not establish investment intent.