SCHEDULE 13G/A

SYROS PHARMACEUTICALS INC

Common Stock, $0.001 par value · CUSIP: 87184Q206

Event date: 2024-12-31

Reporting persons may disclose overlapping interests. Their amounts are shown individually and are not added into a filing total.

Filing-level shares

Unavailable

Percent of class

Unavailable

• Avidity Partners Management LP

  Shares: 2,048,020.00 · Class: 7.6%

• Avidity Partners Management (GP) LLC

  Shares: 2,048,020.00 · Class: 7.6%

• Avidity Capital Partners Fund (GP) LP

  Shares: 2,048,020.00 · Class: 7.6%

• Avidity Capital Partners (GP) LLC

  Shares: 2,048,020.00 · Class: 7.6%

• Avidity Master Fund LP

  Shares: 781,970.00 · Class: 2.9%

• Avidity Private Master Fund I LP

  Shares: 1,169,610.00 · Class: 4.4%

• David Witzke

  Shares: 0.00 · Class: 0.0%

• Michael Gregory

  Shares: 2,048,020.00 · Class: 7.6%

Amounts are as disclosed in this filing. Schedule type alone does not establish investment intent.